Polycarp came to Rome and defended against the Marcionites

He it was who, coming to Rome in the time of Anicetus caused many to turn away from the aforesaid heretics to the Church of God, proclaiming that he had received this one and sole truth from the apostles,—that, namely, which is handed down by the Church.

Irenaeus of Lyons
Against Heresies, Book III
Chapter III

Heretics claim angels formed creation, but only God did

Those, moreover, who say that the world was formed by angels, or by any other maker of it, contrary to the will of Him who is the Supreme Father, err first of all in this very point, that they maintain that angels formed such and so mighty a creation, contrary to the will of the Most High God.

…With justice, therefore, according to an analogous process of reasoning, the Father of all will be declared the Former of this world, and not the angels, nor any other [so-called] former of the world, other than He who was its Author, and had formerly been the cause of the preparation for a creation of this kind.

…He formed all things that were made by His Word that never wearies. For this is a peculiarity of the pre-eminence of God, not to stand in need of other instruments for the creation of those things which are summoned into existence. His own Word is both suitable and sufficient for the formation of all things, even as John, the disciple of the Lord, declares regarding Him: “All things were made by Him, and without Him was nothing made.”

Irenaeus of Lyons
Against Heresies Book II
Chapter II

Heresies give birth to other heresies and continue to divide

Many offshoots of numerous heresies have already been formed from those heretics we have described. This arises from the fact that numbers of them—indeed, we may say all—desire themselves to be teachers, and to break off from the particular heresy in which they have been involved. Forming one set of doctrines out of a totally different system of opinions, and then again others from others, they insist upon teaching something new, declaring themselves the inventors of any sort of opinion which they may have been able to call into existence.

Irenaeus of Lyons
Against Heresies Book I
Chapter XXVIII